منابع مشابه
Arginine-rich cell-penetrating peptides.
Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
متن کاملIntracellular Delivery of Histidine and Arginine Rich Cell Penetrating Peptides into HeLa cell Line
Most bioactive macromolecules, such as DNA and RNA, cannot permeate into cells freely from outside the plasma membrane. Cell penetrating peptides are a group of short peptide sequences that are able to transverse the cell membrane for mediating gene into living cells. In this study we demonstrate two cell penetrating peptides 5H-R9-C and 7H-R9-7H-C. These peptides are synthesized by solid phase...
متن کاملA Gene Delivery Method Mediated by Three Arginine-rich Cell-penetrating Peptides in Plant Cells
The transient gene delivery systems are generally mediated by viral infection, particle bombardment, electroporation, and microinjection for transferring exogenous DNAs into host cells. Recently, the peptide-mediated DNA delivery system became a novel tool for gene transfer, and these peptides, such as cell-penetrating peptides (CPPs), contained the ability of permeating plasma membranes and ca...
متن کاملCellular internalization of quantum dots noncovalently conjugated with arginine-rich cell-penetrating peptides.
Protein transduction domains comprised of basic amino acid-rich peptides, can efficiently deliver covalently fused macromolecules into cells. Quantum dots (QDs) are luminescent semiconductor nanocrystals that are finding increasing application in biological imaging. Previous studies showed that protein transduction domains mediate the internalization of covalently attached QDs. In this study, w...
متن کاملCXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV.
CXCR4 is a coreceptor of HIV-1 infection in host cells. Through a photocrosslinking study to identify receptors involved in internalization of oligoarginine cell-penetrating peptides (CPPs), we found that CXCR4 serves as a receptor that stimulates macropinocytic uptake of the arginine 12-mer peptide (R12) but not of the 8-mer. We also found that stimulating CXCR4 with its intrinsic ligands, str...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2009
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2009.11.046